At the same time, The IgG Fc region of SIRPαFc can bind to the high-affinity receptor FcγRI (CD64) as well as to the low-affinity receptors FcγRII (CD32) and FcγRIII (CD16) on macrophages to further enhance macrophage-mediated ADCP, tumor antigen presentation, and effective anti-tumor activity. Here, FCGR3A is linked to neoplasm.