CD4 and systemic lupus erythematosus: In the next step, we examined in vitro the effects of rapamycin, a mTORC1 inhibitor, and 2DG, a glycolysis inhibitor, on cell metabolism, differentiation, and function in stimulated memory CD4+ cells obtained from HDs, as only a few CD4+CD45RA- memory T cells were obtained from the patients with SLE.