Considering in detail of these populations, the percentage of IFN-γ producing-T-bet+ cells among CD45RA-Foxp3lo non-suppressive cells was higher while the percentage of IFN-γ non-producing-T-bet+ cells among CD45RA-FoxP3hi activated-Treg cells was lower in patients with SLE, compared to the control (Figures 3B, C). This evidence concerns the gene IFNG and systemic lupus erythematosus.