IFNG and obesity due to melanocortin 4 receptor deficiency: Adipocyte MHCII begins to increase at 2 weeks of HFD, and the expression of pro-inflammatory Th1 marker genes Tbx21 and Ifng in adipose tissue resident T cells (ART) increase at 2–3 weeks following HFD, suggesting that adipocyte MHCII may mediate Th1 cell activation and trigger obesity-induced adipose inflammation.