MAPT and Alzheimer disease: Because published evidence demonstrated that the hyperphosphorylation of Tau protein was significantly upregulated in the hippocampi of AD patients (26), we next wanted to assess the p-Tau status in SH-SY-5Y cells exposed to various concentrations of Pg-LPS and PGDHC using two antibodies that recognize hyperphosphorylated tau at Ser396 and Thr212/Ser214 sites by Western blot assay.