MAPK1 and glioblastoma: As shown in Figure 4, the pathways enriched in PD-L1high GBM include (1) NF-kappa B signalling pathway; (2) apoptotic process; (3) positive regulation of interferon-gamma production; (4) Fc gamma R-mediated phagocytosis; (5) positive regulation of interleukin-10 production; (6) response to interferon-gamma; (7) negative regulation of ERK1 and ERK2 cascade; (8) mTOR signalling pathway; (9) innate immune response; (10) Cytokine-cytokine receptor interaction.