By using transcriptional gene expression data from CGGA (The Chinese Glioma Genome Atlas) and TCGA (The Cancer Genome Atlas) databases, we depicted the immune landscape associated with PD-L1 in GBM and proposed that PD-L1-mediated immunosuppression may correlate with the infiltration and M2-polarization of macrophages. This evidence concerns the gene CD274 and central nervous system cancer.