As such, elevated levels of sPD-1 have been detected in several cancers such as NSCLC (Non-small cell lung carcinoma), DLBCL, CLL (Chronic lymphocytic leukemia), NPC (Nasopharyngeal carcinoma), HCC, pancreatic adenocarcinoma, advanced rectal cancer, and metastatic melanoma (81–92) (Figure 3). The gene discussed is HOXD13; the disease is B-cell chronic lymphocytic leukemia.