The risk for development into a pre-leukemic myeloproliferation state was heightened in mice with Tet2-deficinent expression in hematopoietic cells, which was similarly recapitulated in Tet2-deficient germ-free mice upon colitis induction or in response to systemic bacterial stimuli such as treatment with a TLR2-agonist (146). Here, TET2 is linked to colitis.