Juxtapose, in the conditions of unresolved inflammation, TLR4 and caspase-4/11 activation can result in the amplified innate immune signaling, systemic overexpression of the pro-inflammatory mediators and pyroptosis which prompts the onset of sepsis syndrome and a fatal septic shock (15, 22, 38, 88). The gene discussed is TLR4; the disease is systemic inflammatory response syndrome.