CD4 and colorectal neoplasm: These results are consistent with earlier reports that CD4+CD8αβ+ TL infiltrating urological (51) or colorectal tumors (34), or the skin of some aGVHD patients (35) display overall similar Tr-1 cytokine production profile, and they are reminiscent of another report showing that helper TL-derived CD4+CD8α+ T cells from the colonic lamina propria of patients with inflammatory bowel disease secrete IL-10 (52).