SOD1 and amyotrophic lateral sclerosis: Similarly, we propose that, differently from MS, MCs have a role in early degeneration in peripheral nervous system, affecting myelin and Schwann cells functions and having a ripple effect on neuronal damage, an hypothesis consistent with the evidence that ALS is a motor neuron pathology that in SOD1 ALS mouse model as well as in ALS patients affects first distal axons (4, 78, 79).