SOD1 and amyotrophic lateral sclerosis: Finally, histaminergic system is dysregulated in ALS animals (70) and recent work demonstrated that treatment of SOD1-G93A mice with the antihistaminergic drug clemastine is able to reduce microgliosis, to enhance motor neuron survival (71), and to improve neurological symptoms (72), thus supporting the idea of a role for mast cells in the very early phases of ALS.