Since the most relevant sign of ALS disease regards motor functions, we evaluated the health status of the peripheral nerve transmission analyzing nerve endings (NMJ), motor axons (myelinated fibers in sciatic nerves), and motor neurons, in both presymptomatic (2 months) and symptomatic (4 months) SOD1-G93A mice. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.