Also, as in B6 mice, MOG-specific Th1 (IFN-γ-producing) and Th2 (IL-5-producing) cells expanded equally in prophylactic OM-MOG and vehicle DR2b.Ab° mice showing no alteration of effector T cell maturation or overt Th1/Th2 immune deviation by OM-MOG (Figure 4B). The gene discussed is MOG; the disease is ocular melanoma.