Therapeutic OM-MOG mice showed reduced CNS inflammation, as shown by mononuclear cell infiltration (Figures 3A, D) and Iba1-immunostaining of macrophages/microglia (Figures 3C, D), demyelination (Figures 3B, D), and axonal damage (Figure 3D), compared to vehicle mice. The gene discussed is AIF1; the disease is ocular melanoma.