RNA levels for Chi3l3, which encodes the alternative type 2 macrophage marker Ym1, were very low in spleen of mice injected with vehicle or OM-MOG (Chi3l3), or untreated naïve mice (Mrc1, Mmp9, Il1β) prior to the induction of EAE (Figure 7A) and increased in both injected groups during EAE with significantly increased levels in OM-MOG mice (Figure 7A). Here, MMP9 is linked to ocular melanoma.