Increased proportions of CD11b+CD11c+ and CD11b+CD11c- macrophages, and CD11b-CD11c+ DC producing the inhibitory costimulatory ligand PD-L1 were present in DLN and spleen of EAE mice as soon as one day after the first i.d. administration of OM-MOG compared to vehicle controls (Figure 7C). This evidence concerns the gene CD274 and ocular melanoma.