However, in an autoimmune environment such as EAE, mannosylated and mannan-conjugated peptides clearly induce antigen-specific immune tolerance (23, 24), and this is further demonstrated here where prophylactic OM-MOG did not prevent the induction of EAE by a different myelin antigen, PLP178-191 in B6 mice, or reduce ex vivo T cell proliferation responses to polyclonal stimulation with anti-CD3 antibody. The gene discussed is MOG; the disease is ocular melanoma.