We previously showed that PLP139-151-induced EAE in SJL/J mice is prevented by prophylactic OM-PLP139-151 but not OM-MBP83-99, and that MOG-EAE in B6 mice is prevented by OM-MOG but not OM-PLP178-191, demonstrating peptide specificity of OM-peptide tolerance (24). The gene discussed is MOG; the disease is ocular melanoma.