To test whether reduction of IL-2 signaling and proliferation responses in MOG-specific T cells might underlie the beneficial effects of OM-MOG in EAE, we modeled the situation in DR2b.Ab° mice in vitro using antigen cross-presentation assays between bone marrow-derived DC from DR2b.Ab° mice, and I-Ab-restricted MOG-specific splenocytes from 2D2 transgenic mice (29), and measured T cell proliferation responses as read-out. This evidence concerns the gene IL2 and ocular melanoma.