As in prophylactic OM-MOG B6 mice (24), antigen-specific T cell proliferation responses in prophylactic OM-MOG DR2b.Ab° mice, dpi 13 with MOG/CFA (for T cell priming) (Figure 4A), or 17 and 36 dpi with MOG/CFA/PTx (for MOG-EAE), were consistently reduced compared to cells from vehicle controls. Here, MOG is linked to ocular melanoma.