Further support for OM-MOG-induced T cell anergy is given by the finding of increased proportions of antigen-specific CD4+ FoxP3- splenocytes producing high levels of folate receptor 4 (FR4) (CD4+FoxP3-CD44hiFR4hi) in prophylactic OM-MOG B6 mice (Figure 5D). This evidence concerns the gene IZUMO1R and ocular melanoma.