MOG and ocular melanoma: As in B6 mice (24), vehicle DR2b.Ab° mice showed large confluent lesions with mononuclear cell infiltration, demyelination and axonal damage in the spinal cord white matter (Figure 2, upper and middle panels), while OM-MOG mice showed very low levels of inflammatory cell infiltration, mainly meningeal, and no demyelination or axonal damage (Figure 2, lower panels).