The immune checkpoint regulator gene, PD-L1, was also significantly increased in both conditions, while the extracellular matrix glycoprotein SPAR-C was enhanced only in PC3 cells treated with TRIB1 siRNA (p = 0.01) (Figures 8C, F), hinting a role for TRIB1 in the regulation of cancer immune escape and invasion properties. Here, CD274 is linked to cancer.