Our in-silico analysis indicated that multiple “high-confidence” miRNAs are predicted to bind to the 3’UTR of TRIB1. So far, only miR-23a and miR-224-5p have been experimentally validated and shown to downregulate TRIB1 expression in hepatocellular carcinoma and prostate cancer models, respectively (47, 55). This evidence concerns the gene TRIB1 and hepatocellular carcinoma.