Whereas HMGB1 is a direct chemoattractant for eosinophils (50), IL-33 appears to recruit eosinophils only indirectly, via stimulation of tumor-released chemokines, such as CCL24 (51, 52), or through the activation of IL-5 producing ILC2 (53–55) and mast cells (56). This evidence concerns the gene HMGB1 and neoplasm.