Migration to the TME can be mediated by eotaxins (eotaxin-1/CCL11, eotaxin-2/CCL24, eotaxin-3/CCL26) that bind the CCR3 receptor highly expressed on eosinophils (47, 48) and by alarmins (i.e., HMGB1 and IL-33) released from dying tumor cells (22, 49). The gene discussed is HMGB1; the disease is neoplasm.