In fact, IL-33 can directly activate human (59, 60) and mouse (52, 61) eosinophils by up-regulating activation markers (i.e. CD69), adhesion molecules (i.e., ICAM-1 and CD11b/CD18), and the degranulation markers CD63 and CD107a, resulting in the killing of several tumor cell types (51, 52, 62, 63). The gene discussed is CD69; the disease is neoplasm.