Since CD4+ vs CD4- iNKT cells display overlapping yet a distinct range of functional heterogeneity in terms of Th1 vs Th2 cytokine production profile and cytotoxicity (10, 12), it is important to obtain as homogenous population as possible in order to maximize anti-tumor immunity or anti-inflammatory properties of expanded iNKT cells as cell therapy product. Here, CD4 is linked to neoplasm.