CD4 and Alzheimer disease: It may be supposed that myeloid cells, primarily microglia, sense initial tissue damage (inflammatory CD4+ T cell-mediated and neurotoxic Aβ/phosphorylated tau protein-mediated damage in MS and AD, respectively), activate, upregulate MHC-I expression, and start the production of inflammasome-related cytokines and chemokines to recruit CD8+ T cells (124, 167, 170).