To harmonize these findings with the long-standing view of MS as a CD4+ T-cell-driven disease (128), it was hypothesized that following the disease initiation CD4+ T cells (the key drivers of the disease initiation) in MS/EAE are eliminated by apoptosis (124, 129), so CD8+ T cells take on a leading role (130, 131). The gene discussed is CD4; the disease is myeloid sarcoma.