On the other hand, there are data indicating that (i) CD8+ T cells are the predominant type of T cells in MS brain lesions (8–10) and (ii) NCI development in AD patients and transgenic mouse AD models coincides with CD8+ T cells' infiltration into cognitively relevant brain structures (11, 12, 24–27). The gene discussed is CD8A; the disease is myeloid sarcoma.