Differences of RIPKs between AOSD and HC were further compared, as shown in Figure 3B, RIPK1 (AOSD vs. HC, 49.68 vs. 24.77%) and RIPK3 (AOSD vs. HC, 51.3 vs. 25.97%) in lymphocytes of AOSD patients were significantly higher than that of HC group (p=0.0003 and p=0.0002, respectively). The gene discussed is RIPK3; the disease is adult-onset Still disease.