Ifitm3–/– mice are more sensitive to multiple alphaviruses, including CHIKV, VEEV, SFV, SINV, and O’nyong-nyong virus (ONNV), than wild-type mice, and higher viral loads can be detected in multiple organs of ifitm3–/– mice, indicating that IFITM3 can limit the infection and pathogenicity of alphavirus (65). This evidence concerns the gene IFITM3 and infection.