One study used human aortic endothelial cells (HAECs) to model S. mutans interactions during IE, and while they did not directly investigate the role of AgI/II proteins, they instead looked at expression of known AgI/II protein receptor DMBT1 (SAG/gp340) in response to infection (Oho and Nagata, 2019). The gene discussed is DMBT1; the disease is infection.