Emerging studies suggest that TCR IR participates in various liver diseases (including viral hepatitis, liver regeneration, hepatocellular carcinoma, primary sclerosing cholangitis, and alcoholic liver disease) (Chen et al., 2016; Huang et al., 2016; Liaskou et al., 2016; Jiang et al., 2018). This evidence concerns the gene INSR and sclerosing cholangitis.