Examples of this include, the bioactive lipid, lysophosphatidic acid, and its receptor, LPAR-1 in breast cancer (111), chemokines, CXCL8/IL8 and CXCR1 and CXCR2 in melanoma, pancreatic cancer and gastric tumors (112) and CXCL12 and CXCR4 in multiple cancers (113). This evidence concerns the gene CXCL12 and melanoma.