Also Jinho Ko, Kijin Kim, 2013 demonstrated the effectiveness of an aerobic exercise protocol on a treadmill lasting 35–65 min per day, during 5 days per week in the gene expression of manganese containing superoxide dismutase (MnSOD) in the white adipose tissue of mice with obesity induced by high-fat diet (41). Here, SOD2 is linked to obesity due to melanocortin 4 receptor deficiency.