This phosphorylation, performed by the CDK5 at PPARγ S273 (or S245 in isoform 1), does not alter the adipogenic activity of PPARγ, but deregulates a subset of genes, that presented altered expression in obesity and diabetes, such as adiponectin and adipsin (20, 21). The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.