In contrast to the T2DM group, Cleaved caspase3 and caspase3 expressions and apoptosis rate in the T2DM miR-216a-3p inhibitor and T2DM oe-IFN-α2 groups were reduced, while in comparison with the T2DM miR-216a-3p inhibitor group, Cleaved caspase3 and caspase3 expressions and apoptosis rate were elevated in the T2DM miR-216a-3p inhibitor + si-IFN-α2 group (p < 0.05). Here, IFNA2 is linked to type 2 diabetes mellitus.