Compared with the T2DM group, miR-216a-3p expression was significantly reduced but IFN-α2 expression was enhanced in the T2DM miR-216a-3p inhibitor group whereas IFN-α2 expression was increased in the T2DM oe-IFN-α2 group with no significant difference in miR-216a-3p expression. This evidence concerns the gene IFNA2 and type 2 diabetes mellitus.