Western blot revealed that the protein expression of IFNA2 was reduced, but protein expressions of TLR2, TLR4, MyD88, p-IRAK1, and p-IRF3 were increased in the rat myocardial tissues of the T2DM group compared with the normal group (p < 0.05; Figure 2C). The gene discussed is IRF3; the disease is type 2 diabetes mellitus.