In comparison with the normal group, the T2DM, T2DM inhibitor NC, and T2DM oe-NC groups exhibited increased IL-1β, IL-6, and TNF-α levels, increased expressions of TLR4 and MyD88 mRNA and protein levels, as well as significantly increased p-IRAK1 and p-IRF3 protein levels. This evidence concerns the gene MYD88 and type 2 diabetes mellitus.