Compared with the T2DM group, the T2DM miR-216a-3p inhibitor and T2DM oe-IFN-α2 groups showed enhanced cell survival rate, decreased cells in G0/G1 phase, increased cells in S phase, and increased cell viability; however, the opposite was observed in the T2DM miR-216a-3p inhibitor + si-IFN-α2 group compared with the T2DM miR-216a-3p inhibitor group (p < 0.05). Here, IFNA2 is linked to type 2 diabetes mellitus.