ADNP deficiency reduced dendritic spine density and altered synaptic gene expression, both of which were partly ameliorated by CP201 treatment. Adnp+/− mice further exhibited global developmental delays, vocalization impediments, gait/motor dysfunctions, and social/object memory impairment, all partially reversed by daily CP201 administration (systemic/intranasal). This evidence concerns the gene ADNP and Global developmental delay.