ADNP and ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder: Specifically, cellular expression of heterozygous ADNP truncating mutations (representing the majority of the ADNP syndrome cases, e.g., ADNP p.Ser404* or p.Tyr719*, or p.Arg730*) reduced Tau–MT interactions (25) and impaired MT dynamics, in cell culture models (24).