Although a broad array of post-translational modifications and their relationship to specific disease states have been well-characterized [reviewed in (44)], we have focused on the specific role of pathological phosphorylation at Thr175 and the mechanisms by which this culminates in the generation of oligomeric tau and a subsequent tauopathy, including a synergistic role with pathological TDP-43 deposition. Here, MAPT is linked to tauopathy.