MAPT and amyotrophic lateral sclerosis: Both tau immunoreactive inclusions and pathological tau phosphorylation disproportionate for age have been observed in ALS patients affected with cognitive or executive dysfunction (ALSci), typically in the form of dystrophic neurites, neurofibrillary tangle-like structures and pre-tangles, neuritic granules, and tau-immunoreactive tufted astrocytes (109–111).