The median age at disease onset was 72 (range: 19–156) months, which conforms to a previous report of bimodal distribution of anti-MOG seropositivity in patients based on age of onset, with a higher prevalence of encephalopathy observed in the younger group (4–8 years old) and almost exclusively with ON in the older group (13–18 years) (18). This evidence concerns the gene MOG and Encephalopathy.