For example, Salsalate is a nonsteroidal anti-inflammatory drug that decreases t-tau levels and acetylated tau at the K174 residue, ameliorates hippocampal atrophy and memory deficits in PS19 Tg mice (8), and has consequently advanced to phase 1 PSP clinical trial (264). The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.