Based on these findings, two anti-tau vaccines have been tested in AD clinical trials; one targeting S396 and S404 phosphorylated tau (ACI-35) (186) and the other targeting the pathological N-truncated form of tau (AADvac-1 or Axon peptide 108 conjugated to keyhole limpet hemocyanin) (187). The gene discussed is MAPT; the disease is Alzheimer disease.