• Tau phosphorylation in AD brain tissue: S202, T231, S199, Y18, S262, S356 [For a detailed account on phosphorylation sites, see (61, 62)]. • ↑ phosphorylation at Y18, T231 and S199 in post-mortem brain tissue (63). • ↑ phosphorylation at Y18 and T231 in isocortex and transentorhinal cortex depending on Braak stages (63). This evidence concerns the gene MAPT and Alzheimer disease.