MAPT and Mental deterioration: These include the (i) altered exon 10 splicing of MAPT (31, 32), (ii) correlations between H2 MAPT haplotype and severity of cognitive decline (27), (iii) dysfunction of tau-targeting kinases and phosphatases (55, 56, 64, 83), (iv) increased soluble hyperphosphorylated tau (32), (v) altered levels of t-tau in the brain and CSF (32, 96, 97, 209), and (vi) presence of brain NFTs (27, 98, 99).