In contrast to the therapeutic strategies discussed in sections Therapeutic Strategies to Target Pathological Forms of Tau, Mitigation of tau-induced cellular alterations by stabilizing microtubules, Modulation of MAPT Gene Expression of this review, the relevance of these pathways remains to be demonstrated in models of HD, and the functional and mechanistic contributions of UPS dysfunction to HD pathology are unclear (269). The gene discussed is MAPT; the disease is Huntington disease.