IL10 and Sepsis: Sepsis stimulates emergency myelopoiesis, which induces the expansion of MDSCs (36) Brudecki et al. (37) demonstrated that during the early phase, MDSCs secreted nitric oxide (NO) and pro-inflammatory cytokines, whereas in the later chronic phase, MDSCs expressed Arg1 and IL-10 proteins in a mouse polymicrobial sepsis model.