Twenty-eight days after stroke, the mNSS scores of the gsdmd−/− group and WT group were 3.75 ± 0.4523 and 6.25 ± 0.6216, respectively (Figure 5G, P < 0.001), indicating that the absence of GSDMD significantly promoted neurological recovery from I/R injury. Here, GSDMD is linked to stroke disorder.