CD274 and Huntington disease: Most notably, the interferon response genes, IFITM3 (encoding Interferon-induced transmembrane protein 3), IFI6 (encoding Interferon alpha-inducible protein 6), IRF7 (Interferon regulatory factor 7), CD274 (encoding Programmed death-ligand 1), and NDST1 (encoding N-deacetylase-N-sulfotransferase-1) were induced in both peripheral blood and choroid plexus in HD.