Indeed, the CSF concentrations of immune cell–specific cell surface markers, such as CD27 (predominantly shed from T cells especially CD8+), CD21 (shed from B cells, especially naive B cells), CD23 (predominantly shed by activated DCs and memory B cells), and CD14/CD163 (predominantly shed by monocytes and macrophages) are equally increased in all MS subtypes (64), indicating similar levels of inflammation in the intrathecal compartment of RRMS and PMS subjects. Here, CD8A is linked to premenstrual tension.