After adjusting for physiological gender and age effects and analyzing only samples from untreated subjects, we identified (and validated in the independent cohort) MS-specific changes in the blood: increased proportion of CD4+ T cells (among all T cells) observed in all MS subtypes and an associated increase in CD4/CD8 ratio even though the latter validated statistical significance only in the PMS cohort. This evidence concerns the gene CD4 and myeloid sarcoma.