CD4 and major depressive disorder: However, the Global weaknesses with spared verbal recognition profile (Profile 3) was more likely to be non-Hispanic White, have lower WRAT-4 scores, had more IADL dependence and higher BDI-II scores, was more likely to have a current diagnosis of MDD, have higher log plasma viral loads, lower current and nadir CD4 counts, and a shorter duration of HIV disease compared to the profile demonstrating Weakness in motor function (Profile 1).