In addition, a well-designed study found transgenic mice with overexpression of muscle PGC-1α are resilient to stress-induced depression and control plasma and brain kynurenine/kynurenic acid balance, suggesting PGC-1α1-PPAR axis in skeletal muscle as a novel target of exercise in the prevention of depression (14). The gene discussed is PPARGC1A; the disease is major depressive disorder.