BDNF and major depressive disorder: This is particularly illustrated by a study conducted by Choi et al. (103) in which curcumin administration permitted an improvement of the depressive behavior induced by chronic unpredictable stress in mice alongside reduced hippocampal neuronal cell death, attenuated long-term depression, increase in BDNF, and COX-2 inhibition, suggesting neuroprotection via anti-inflammatory effects.