ATP6AP2 and hypertensive disorder: Although previous studies reported that Ang II can access the PVN and RVLM in hypertension due to blood brain barrier breakdown (Biancardi et al., 2014; Biancardi and Stern, 2016), more recent studies have shown that the PRR represents the main source of local Ang II production in the brain (Li et al., 2014, 2015b).