Although previous studies reported that Ang II can access the PVN and RVLM in hypertension due to blood brain barrier breakdown (Biancardi et al., 2014; Biancardi and Stern, 2016), more recent studies have shown that the PRR represents the main source of local Ang II production in the brain (Li et al., 2014, 2015b). Here, ATP6AP2 is linked to Hypertension.