The key findings of this study include the following: (1) the PRR is expressed in neurons, but not astrocytes, in both the PVN and RVLM; (2) PRR immunoreactivity in both the PVN and RVLM is significantly elevated in HTN subjects; and (3) PVN-PRR immunoreactivity is positively correlated with sBP. This evidence concerns the gene ATP6AP2 and hypertensive disorder.