APOE and cerebrovascular disorder: This may be partially explained by epidemiological studies which show that the majority of risk factors for both types of dementia are related to cerebrovascular disease and include APOE-ε4 genotype, advanced age, hypertension, hyperlipidemia, diabetes, obesity, and smoking (Corder et al., 1993; Kivipelto et al., 2006; Gorelick et al., 2011; Viticchi et al., 2015; Santos et al., 2017; Vos et al., 2017; Deckers et al., 2019).