AQP4 and stroke disorder: Wang et al. (2017) found that stroke increased focal CSF solute trapping within the area of infarction. Venkat et al. (2017) showed that multiple microinfarctions decreased Aquaporin-4 (AQP4) levels resulted in glymphatic dysfunction. Furthermore, Howe et al. (2018a, 2019) reported BM remodeling increased peri-infarct deposition of CSF Aβ1–40 in aged animals with stroke. These studies also show a consistent effect of acute stroke on inhibiting perivascular transport and promoting the sequestration of CSF solutes, including Aβ1–40, within infarcted brain regions.