Moreover, ACE2-deficient mice chronically treated with Ang II infusion displayed a more than 5-fold higher renal Ang II concentration than Ang II-treated wild-type animals, thereby suggesting that the more severe hypertension in ACE2-deficient mice may be attributed to an impaired metabolism of Ang II in the kidney (Gurley et al., 2006). Here, ACE2 is linked to hypertensive disorder.