ACE and Hypertension: These concerns were primarily based on findings that ACE inhibitors (ACEi) or angiotensin II type 1 receptor (ARB) upregulate the expression and activity of ACE2, the SARS-CoV-2 receptor, in the kidneys and heart of experimental models of hypertension (Ferrario et al., 2005; Jessup et al., 2006; Wang et al., 2016).