In rats with chronic kidney disease (CKD) and hypertension, the administration of the DPP4 inhibitor sitagliptin ameliorated hypertension, kidney function and restored the cardiac ratio of Ang II to Ang-(1-7) concentrations in the heart by reducing the levels of Ang II and increasing the content of Ang-(1-7) (Beraldo et al., 2019). This evidence concerns the gene ANG and chronic kidney disease.