Extrapolating data from SARS-CoV to SARS-CoV-2, one may postulate that the imbalance in the signaling and actions of products of ACE/ACE2, generated by the loss of ACE2 cell surface expression due to SARS-CoV-2 infection, may lead to severe acute respiratory failure in COVID-19 (Kuba et al., 2005). Here, ACE2 is linked to acute respiratory failure.