Abnormal activation of RAS components, ultimately leading to the upregulation of angiotensin II (Ang II) and activation of its angiotensin II type 1 receptor (AT1R), contribute to the development and progression of hypertension (Carson et al., 2001; Dahlof et al., 2002; Crowley et al., 2005, 2006; Gurley et al., 2011). Here, AGTR1 is linked to hypertensive disorder.