GATAD1 and heart failure: Yang et al. (2016) generated a gatad1 knockout zebrafish mutant by TALEN technology as well as a transgenic fish line overexpressing the human GATAD1-S102P variant in cardiomyocytes. While gatad1 knockout fish exhibited a mild heart failure–like phenotype after stress, the cardiomyocyte-specific overexpressing GATAD1-S102P transgenic fish have increased mortality, concurrent with a substantially enlarged ventricular chamber and decreased papillary muscle density, suggesting cardiac remodeling.