KCNJ8 and hypertrichotic osteochondrodysplasia Cantu type: Tessadori et al. (2018) reported a KCNJ8 V65M knock-in model in adult zebrafish. The heterozygous knock-in zebrafish had substantially enlarged ventricles and enhanced cardiac output and contractile function, which was similar to the characteristic signs in patients with Cantú syndrome. Through confirming the causality of the KCNJ8 V65M mutation, this study provided the feasibility of modeling patient-specific mutations in adult zebrafish via knock-in technology.