Blockade of IL-6R through administration of an anti-murine IL-6R antibody in C26-bearing mice also showed attenuated muscle loss and reduced expression of cathepsin B and L in muscle compared to tumor-bearing controls (Fujita et al., 1996), highlighting the requirement of IL-6 and IL-6 signaling in this experimental model of cancer cachexia. The gene discussed is IL6R; the disease is cancer.