In addition, intra-muscularly inoculated LLC-tumor bearing WT mice displayed increased protein degradation and loss of muscle mass, which was prevented in transgenic littermates overexpressing the soluble TNF receptor type 1 protein (sTNF-R1) to inhibit the actions of local or circulating TNF-α (Llovera et al., 1998). The gene discussed is TNF; the disease is neoplasm.