In line, hyperactivation of STAT3 signaling through Gp130 activation in gp130F/F knock-in mice with a k-Ras-driven lung carcinoma developed cachexia with reduced muscle and fat mass and reduced life expectancy compared to k-Ras mice without Gp130 hyperactivation (Miller et al., 2017). The gene discussed is KRAS; the disease is Cachexia.