CRP and Cachexia: Although the liver is a central regulator of metabolism, there is relatively little research examining a role of the liver in the association between inflammation and cachexia, which is surprisingly considering the liver is the major site for muscle proteolysis-derived amino acids for utilization in gluconeogenesis and acute-phase protein synthesis, such as CRP (Argilés et al., 2001), and elevated CRP levels are the most frequently applied additional criteria to assess cachexia (Fearon et al., 2006).