Mice inoculated with tumors that overexpress IFN-γ presented with severe cachexia, and IFN-γ inhibition prior to inoculation attenuated body weight loss (Matthys et al., 1991), implying IFN-γ secretion rather than other tumor-dependent effects in the development of tissue depletion in this model. The gene discussed is IFNG; the disease is Cachexia.