In vivo, IP injection of the SK4 blocker reduced the occurrence of SVT, NSVT, or VPC visible at ECG in CPVT mice in addition to a negative chronotropic effect and an elongation of the PRi (Haron-Khun et al., 2017). Here, KCNN4 is linked to catecholaminergic polymorphic ventricular tachycardia.