RYR2 and catecholaminergic polymorphic ventricular tachycardia: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a stress-induced ventricular arrhythmia associated with cytoplasmic calcium leakage due to mutations in calsequestrin 2 (CASQ2) (Postma et al., 2002; Wang et al., 2005), ryanodine receptor (RyR2) (Laitinen et al., 2001; Eldar et al., 2003), triadin (Priori et al., 2001), or calmodulin (Roux-Buisson et al., 2012).