CLEC4E and chronic kidney disease: In this present study, we used a novel 5/6 nephrectomy induced CKD mouse model in vivo and an inflammatory macrophage model in vitro to study the protective effects of A&P on kidney and intestine of CKD mice and explore whether A&P inhibited inflammation of kidney and intestine in CKD through regulating Mincle signaling, that may provides a new option for the treatment of CKD.