On the other hand, HE, Masson’s trichrome and Picrosirius Red stained atrial sections exhibited significant reduction in the levels of atrial fibrosis in Ang II + apelin group compared with Ang II group (1.45 ± 0.11 vs 6.12 ± 0.16, P < 0.001; 1.49 ± 0.25 vs 8.15 ± 0.23, P < 0.001; 1.98 ± 0.64 vs 9.59 ± 0.56, P < 0.001, respectively), and were in fact equivalent to the control group (1.45 ± 0.11 vs 1.24 ± 0.09, P = 0.08; 1.49 ± 0.25 vs 1.25 ± 0.11, P = 0.06; 1.98 ± 0.64 vs 2.11 ± 0.47, P = 0.42, respectively), (Figure 2). This evidence concerns the gene APLN and hereditary elliptocytosis.