WNT10A and tooth agenesis: Biallelic WNT10A variants were proposed to be the pathogenic factor for tooth agenesis with complete penetrance, while single allelic variants, presenting with a significantly higher frequency in tooth agenesis patients, were considered to be a predisposing factor for tooth agenesis with reduced penetrance (Mues et al., 2014; Guazzarotti et al., 2018).