WNT10A and tooth agenesis: Biallelic WNT10A variants were proposed to be a pathogenic factor for tooth agenesis with complete penetrance, while a single allelic variant, presenting in a significantly higher frequency in tooth agenesis patients, was considered to be a predisposing factor for tooth agenesis with reduced penetrance (Mues et al., 2014; Guazzarotti et al., 2018).