The upregulation of autophagy induction complex-tcs1/tcs2 and “core” autophagy machinery, such as the ulk1 complex (ulk1a, ulk2, atg13, atg101, and rb1cc1), pik3c3 complex (atg14 and pik3c3), atg8 conjugation system (map1l3c3a, map1l3c3cl, atg4c, and gabarapb), and atg9 complex (atg9a, atg9b, wipi1, and wdr45) may provide a protective mechanism for protein folding disorders to maintain proteostasis (Mathai et al., 2017). The gene discussed is POLR1D; the disease is proteostasis deficiencies.