In addition to 4T1 cells, cancer-associated fibroblasts (CAFs) also release Ccl2 and Ccl5 to recruit monocytes/macrophages and re-polarize M1 macrophages to M2-like TAMs (Soria and Ben-Baruch, 2000; Owen et al., 2011; Biswas et al., 2014; Katanov et al., 2015; Madera et al., 2015; Córdova et al., 2017; Liubomirski et al., 2019). This evidence concerns the gene CCL5 and cancer.