In previous studies, vascular endothelial growth factor (VEGF) and the cytokine interleukin-6 (IL-6) have been identified as potential mediators in the development of OHSS because of their vasoactive properties, which increase the permeability of capillaries (Motro et al., 1990; Pellicer et al., 1999; Miller et al., 2016). The gene discussed is VEGFA; the disease is ovarian hyperstimulation syndrome.