In addition, Nox2 (a member of the NADPH oxidase family), GRK2 (G protein-coupled receptor kinase 2) and NO-producing enzymes (such as inducible nitric oxide synthase) in microglia regulate oxidative and nitrosative stress during inflammation, contributing to the amplification of pro-inflammatory mediators production, as well as long-term brain deficits after sepsis (Hernandes et al., 2014; Widmann and Heneka, 2014; Kawakami et al., 2018). Here, GRK2 is linked to Sepsis.