NT5E and hypersensitivity reaction disease: Although much work has been published on the role of adenosine and its receptors in allergic asthma, and adenosine signaling might represent a therapeutic target (Brown et al., 2008; Polosa and Blackburn, 2009; Alfieri et al., 2012; Cicala and Ialenti, 2013), very little is known on the role of CD73 in the development of allergic sensitization as a major cause of those morphological and functional changes of airways that could facilitate asthma development (Schreiber et al., 2008; Neuberger et al., 2017).