Abbreviations: DBD, DNA-binding domain; G6PC, Glucose-6-phosphatase; LBD, Ligand-binding domain; PGC1, Peroxisome proliferator-activated receptor γ coactivator 1; T2DM, Type 2 diabetes mellitus; SREBP1, Sterol regulatory element-binding protein 1; UCP1, Uncoupling protein 1. The gene discussed is UCP1; the disease is type 2 diabetes mellitus.