Alpha-synuclein levels are increased throughout the enteric neurons of children with intestinal inflammation (Stolzenberg et al., 2017), adults with Crohn's disease (Prigent et al., 2019) and a high proportion of healthy individuals without a known neurodegenerative diagnosis during life (Gold et al., 2013), supporting a proposed role of alpha-synuclein in normal gut function and immunity (Barbut et al., 2019). The gene discussed is SNCA; the disease is Crohn disease.