TLR1 and Parkinson disease: Given that TLR1 expression and TLR1/TLR2 function exhibit an age-related decline (Van Duin et al., 2007), coupled with a lack of validation for TLR1 rs4833095 and TLR2 rs3804099 in both studied cohorts, further investigations of larger cohorts are required to clarify the relationship between TLR1, TLR2, and PD risk.