Analysis between controls and PPMI demonstrated an increasing step-wise pattern for PD risk with TLR2 rs3804099; TC heterozygotes exhibited significantly higher PD risk in naïve [OR = 1.410 (1.016–1.956), p = 0.040], and corrected regression [OR = 1.432 (1.031–1.990), p = 0.032]; a greater odds ratio was evident for minor homozygotes in naïve [1.553 (1.027–2.350), p = 0.037] and corrected models [OR = 1.553 (1.024–2.354), p = 0.038]. This evidence concerns the gene TLR2 and Parkinson disease.