TLR1-TLR2 heterodimers recognize triacylated microbial lipoproteins from gram-negative bacteria and mycoplasma to cause an innate immune response (Burgueño and Abreu, 2020), and variants in TLR1 and TLR2 were associated with PD risk in the APDR and PPMI cohorts, respectively. This evidence concerns the gene TLR2 and Parkinson disease.