Subsequent analyses of TLR2 rs3804099 heterozygotes with PGLYRP4 rs10888557 GC genotype (control = 30, PD = 45) demonstrated significantly increased PD risk in naïve [OR = 1.883 (1.128–3.143), p = 0.015] and corrected models [OR = 1.890 (1.132–3.156), p = 0.015], suggesting an interactive allelic effect. Here, TLR2 is linked to Parkinson disease.