Similarly, minor CC homozygotes of TLR1 rs4833095 had significantly lower PD risk than major homozygotes in the APDR cohort in both naïve [OR = 0.246 (0.084–0.717), p = 0.010] and corrected models [OR = 0.252 (0.086–0.737), p = 0.012], but this was not replicated in the PPMI analysis. This evidence concerns the gene TLR1 and Parkinson disease.