Additionally, it is important to acknowledge that the SNP rs10888557 is located between PGLYRP4 and its neighboring gene S100A9. Data from NCBI (assembly GRCh38.p12) demonstrates that SNP rs10888557 is ~4,000 base pairs away from the 5' end of PGLYRP4 and ~5,000 base pairs from the 5' end of S100A9. One of the S100 calcium-binding proteins, S100A9 is a pro-inflammatory mediator with amyloidogenic properties, and has been widely implicated in inflammation, cancer and neurodegeneration. This evidence concerns the gene S100A9 and cancer.