Given that TLR1 expression and TLR1/TLR2 function exhibit an age-related decline (Van Duin et al., 2007), coupled with a lack of validation for TLR1 rs4833095 and TLR2 rs3804099 in both studied cohorts, further investigations of larger cohorts are required to clarify the relationship between TLR1, TLR2, and PD risk. The gene discussed is TLR2; the disease is Parkinson disease.